Search results for "Psychoactive substance"
showing 4 items of 4 documents
Chiral Serum Pharmacokinetics of 4-Fluoroamphetamine after Controlled Oral Administration
2021
Abstract Over the last two decades, misuse of 4-fluoroamphetamine (4-FA) became an emerging issue in many European countries. Stimulating effects last for 4–6 hours and can impact psychomotor performance. The metabolism of amphetamine-type stimulants is stereoselective and quantification of (R)- and (S)-enantiomers has been suggested for assessing time of use. To date, no data on enantioselective pharmacokinetics is available for 4-FA in serum samples. An enantioselective liquid chromatography−tandem mass spectrometry (LC–MS-MS) method was developed using a chiral Phenomenex® Lux 3 μm AMP column. Validation of the method showed satisfactory selectivity, sensitivity, linearity (0.5–250 ng/mL…
Chemical profiling of the synthetic cannabinoid MDMB-CHMICA: Identification, assessment, and stability study of synthesis-related impurities in seize…
2019
In this work, the most discriminating synthesis-related impurities found in samples from seizures and controlled synthesis of the synthetic cannabinoid MDMB-CHMICA (methyl (S)-2-(1-(cyclohexylmethyl)-1H-indole-3-carboxamido)-3,3-dimethylbutanoate) were characterized. Based on 61 available powder samples of MDMB-CHMICA, 15 key-impurities were assessed, isolated in larger quantities via flash chromatography and structurally elucidated and characterized via high resolution mass spectrometry and nuclear magnetic resonance spectroscopy. Apart from verifying the relation of the impurities to the major component, the interpretation of their chemical structures with distinct structural elements pro…
Controlling the uncontrollable. Self-regulation and the dynamics of addiction
2017
The multidisciplinary research on addictions generally promotes the assumption that addictive behavior is caused and maintained by the external psychoactive substance, which accordingly is consider...
Osoby będące pod wpływem działania substancji psychoaktywnych a bezradność
2022
The chapter discusses the main concepts related to addiction and its diagnosis. The definition of addiction and diagnostic criteria for substance and behavior addiction will be discussed. Formal criteria enabling professional treatment and social understanding of the phenomenon are important for systematising knowledge and clearly presenting the profiles of addicts. The text describes separately the problem of addictions to behavior, listing those most common in the literature. In addition, a discussion is initiated on behaviors that formally do not meet the definition of addiction, although they are associated with some compulsion. In addition, the issues of the experience of the disease a…